Drug resistance is a hot topic issue in cancer research and therapy. Although cancer therapy
including radiotherapy and anti‐cancer drugs can kill malignant cells within the tumor,
cancer cells can develop a wide range of mechanisms to resist the toxic effects of anti‐
cancer agents. Cancer cells may provide some mechanisms to resist oxidative stress and
escape from apoptosis and attack by the immune system. Furthermore, cancer cells may
resist senescence, pyroptosis, ferroptosis, necroptosis, and autophagic cell death by …

The need for naturally occurring constituents is driven by the rise in the cancer prevalence
and the unpleasant side effects associated with chemotherapeutics. Triptolide, the primary
active component of" Tripterygium Wilfordii", has exploited for biological mechanisms and
therapeutic potential against various tumors. Based on the recent pre-clinical investigations,
triptolide is linked to the induction of death of cancerous cells by triggering cellular apoptosis
via inhibiting heat shock protein expression (HSP70), and cyclin dependent kinase (CDKs) …