… This notion also applies to the establishment and maintenance of tolerance to self antigens.
Thus, immune homeostasis is attributed to multiple distinct safety valves that are connected …

… @ for self-antigen on the one hand, and on the nature of the self-… mechanism of self tolerance
has been the technical d&&y … of individual clones of potentially self-reactive lymphocytes. …

… conditions needed to induce tolerance, but it has often been … The state of the art in tolerance
mechanisms was the main … clonal deletion and other possible tolerance mechanisms. …

… mechanisms have evolved to control the activity of these ‘forbidden’ receptors and achieve
immunological self tolerance… cellular and gene maps of self tolerance and immunity will guide …

Using cytotoxic T lymphocyte (CTL) responses to the class I histocompatibility antigen Qa1
and to the minor histocompatibility antigen HY, we show that the immune system maintains a …

… Strategies that override tolerance might enable more … of self tolerance consistent with 'health'.
The first part of this Review summarizes what is known about mechanisms of self tolerance. …

… to maintaining self-tolerance by down-regulating immune response to self and non-self Ags
in an … immune responses to non-self Ags, but also eliciting autoimmune responses to certain …

… IgM that protects its respective self-targets from degradation. We refer to this novel mechanism
as adaptive tolerance. This article discusses the discovery of adaptive tolerance and the …

… anti-self receptors. This process is referred to as the acquisition of self-tolerance. Recent …
explore the mechanisms by which self-tolerance takes place, are the subject of this review. …

… The tolerant state appears to be induced in the thymus since … Nondeletional mechanisms
of tolerance to Mls and MHC can … mechanisms may be responsible for intrathymic tolerance …