[HTML][HTML] Mechanotransduction-induced interplay between phospholamban and yes-activated protein induces smooth muscle cell hypertrophy
The gastrointestinal system is a hollow organ affected by fibrostenotic diseases that cause
volumetric compromise of the lumen via smooth muscle hypertrophy and fibrosis. Many of
the driving mechanisms remain unclear. Yes-associated protein-1 (YAP) is a critical
mechanosensory transcriptional regulator that mediates cell hypertrophy in response to
elevated extracellular rigidity. In the type 2 inflammatory disorder, eosinophilic esophagitis
(EoE), phospholamban (PLN) can induce smooth muscle cell hypertrophy. We used EoE as …
volumetric compromise of the lumen via smooth muscle hypertrophy and fibrosis. Many of
the driving mechanisms remain unclear. Yes-associated protein-1 (YAP) is a critical
mechanosensory transcriptional regulator that mediates cell hypertrophy in response to
elevated extracellular rigidity. In the type 2 inflammatory disorder, eosinophilic esophagitis
(EoE), phospholamban (PLN) can induce smooth muscle cell hypertrophy. We used EoE as …
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