The neonatal mammalian heart is capable of substantial regeneration following injury
through cardiomyocyte proliferation,. However, this regenerative capacity is lost by postnatal
day 7 and the mechanisms of cardiomyocyte cell cycle arrest remain unclear. The
homeodomain transcription factor Meis1 is required for normal cardiac development but its
role in cardiomyocytes is unknown,. Here we identify Meis1 as a critical regulator of the
cardiomyocyte cell cycle. Meis1 deletion in mouse cardiomyocytes was sufficient for …

The neonatal mammalian heart is capable of substantial regeneration following injury
through cardiomyocyte proliferation (Porrello et al, Science 331: 1078–1080, 2011; Proc
Natl Acad Sci USA 110: 187–92, 2013). However, this regenerative capacity is lost by
postnatal day 7 and the mechanisms of cardiomyocyte cell cycle arrest remain unclear. The
homeodomain transcription factor Meis1 is required for normal cardiac development but its
role in cardiomyocytes is unknown (Paige et al, Cell 151: 221–232, 2012; Wamstad et al …