Meta-analysis of the correlation between chronic cerebrospinal venous insufficiency and multiple sclerosis
BA Zwischenberger, MM Beasley… - Vascular and …, 2013 - journals.sagepub.com
BA Zwischenberger, MM Beasley, DL Davenport, ES Xenos
Vascular and Endovascular Surgery, 2013•journals.sagepub.comPurpose: To determine whether a correlation exists between chronic cerebrospinal venous
insufficiency (CCSVI) and multiple sclerosis (MS). Materials and Methods: A meta-analysis
of the current literature was performed to evaluate the frequency of CCSVI, diagnosed by
echo color Doppler criteria, in patients with MS and in normal controls. Results: In all, 19
studies were identified from January 2005 through February 2013; however, 3 studies were
excluded due to duplicate data and 3 additional studies because 0 patients fulfilled CCSVI …
insufficiency (CCSVI) and multiple sclerosis (MS). Materials and Methods: A meta-analysis
of the current literature was performed to evaluate the frequency of CCSVI, diagnosed by
echo color Doppler criteria, in patients with MS and in normal controls. Results: In all, 19
studies were identified from January 2005 through February 2013; however, 3 studies were
excluded due to duplicate data and 3 additional studies because 0 patients fulfilled CCSVI …
Purpose
To determine whether a correlation exists between chronic cerebrospinal venous insufficiency (CCSVI) and multiple sclerosis (MS).
Materials and Methods
A meta-analysis of the current literature was performed to evaluate the frequency of CCSVI, diagnosed by echo color Doppler criteria, in patients with MS and in normal controls.
Results
In all, 19 studies were identified from January 2005 through February 2013; however, 3 studies were excluded due to duplicate data and 3 additional studies because 0 patients fulfilled CCSVI criteria in both MS and control groups. In order to improve homogeneity, 4 outlier studies were also removed from the analysis. Analysis of the remaining 9 studies demonstrated a significant correlation between CCSVI and MS (odds ratio 1.885, P < .0001) with no significant heterogeneity of the studies (I2 = 18, P = .279).
Conclusions
The meta-analysis demonstrated a correlation between CCSVI and MS. However, there was no evidence that CCSVI has a causative role in MS.
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