Metabolic pathway analysis of enzyme-deficient human red blood cells
Five enzymopathies (G6PDH, TPI, PGI, DPGM and PGK deficiencies) in the human red
blood cells are investigated using a stoichiometric modeling approach, ie, metabolic
pathway analysis. Elementary flux modes (EFMs) corresponding to each enzyme deficiency
case are analyzed in terms of functional capabilities. When available, experimental findings
reported in literature related to metabolic behavior of the human red blood cells are
compared with the results of EFM analysis. Control-effective flux (CEF) calculation, a novel …
blood cells are investigated using a stoichiometric modeling approach, ie, metabolic
pathway analysis. Elementary flux modes (EFMs) corresponding to each enzyme deficiency
case are analyzed in terms of functional capabilities. When available, experimental findings
reported in literature related to metabolic behavior of the human red blood cells are
compared with the results of EFM analysis. Control-effective flux (CEF) calculation, a novel …
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