Metabolic Response to Fasting Predicts Weight Gain During Low-Protein Overfeeding: Further Evidence for Spendthrift and Thrifty Metabolic Phenotypes
T Hollstein, T Ando, A Basolo, J Krakoff… - Available at SSRN …, 2018 - papers.ssrn.com
Greater increase in 24-h energy expenditure (24EE) during overfeeding and smaller
decrease in 24EE during fasting (“spendthrift” metabolic phenotype) are associated with
more weight loss during sustained caloric restriction in obese subjects. It is unknown
whether these metabolic characteristics can also defend weight gain during sustained
overfeeding. We conducted the first proof-of-concept study in lean individuals to show that,
after 6 weeks of 150% low-protein overfeeding, metabolically spendthrift subjects gained …
decrease in 24EE during fasting (“spendthrift” metabolic phenotype) are associated with
more weight loss during sustained caloric restriction in obese subjects. It is unknown
whether these metabolic characteristics can also defend weight gain during sustained
overfeeding. We conducted the first proof-of-concept study in lean individuals to show that,
after 6 weeks of 150% low-protein overfeeding, metabolically spendthrift subjects gained …
[HTML][HTML] Metabolic response to fasting predicts weight gain during low-protein overfeeding in lean men: further evidence for spendthrift and thrifty metabolic …
T Hollstein, T Ando, A Basolo, J Krakoff… - The American journal of …, 2019 - Elsevier
Background Greater increase in 24-h energy expenditure (24EE) during overfeeding and
smaller decrease in 24EE during fasting (“spendthrift” metabolic phenotype) are associated
with more weight loss during sustained caloric restriction in overweight subjects. Objectives
The aim of this study was to investigate whether these acute metabolic responses can also
predict weight gain during sustained overfeeding in lean individuals. Methods Seven lean
men participated in this study. Prior to overfeeding, 24EE responses to fasting and 200 …
smaller decrease in 24EE during fasting (“spendthrift” metabolic phenotype) are associated
with more weight loss during sustained caloric restriction in overweight subjects. Objectives
The aim of this study was to investigate whether these acute metabolic responses can also
predict weight gain during sustained overfeeding in lean individuals. Methods Seven lean
men participated in this study. Prior to overfeeding, 24EE responses to fasting and 200 …
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