Methamphetamine (METH), an addictive psycho-stimulant drug exerts euphoric effects on
users and abusers. It is also known to cause cognitive impairment and neurotoxicity. Here,
we hypothesized that METH exposure impairs the glucose uptake and metabolism in human
neurons and astrocytes. Deprivation of glucose is expected to cause neurotoxicity and
neuronal degeneration due to depletion of energy. We found that METH exposure inhibited
the glucose uptake by neurons and astrocytes, in which neurons were more sensitive to …