MicroRNA-221 and-222 regulate radiation sensitivity by targeting the PTEN pathway
C Zhang, C Kang, P Wang, Y Cao, Z Lv, S Yu… - International Journal of …, 2011 - Elsevier
Purpose MicroRNAs (miRNAs) are noncoding RNAs inhibiting expression of numerous
target genes by posttranscriptional regulation. miRNA-221 and miRNA-222 (miRNA-221/-
222) expression is elevated in radioresistant tumor cell lines; however, it is not known
whether and how miRNAs control cellular responses to ionizing irradiation. Methods and
Materials We used bioinformatic analyses, luciferase reporter assay, and genetic
knockdown and biochemical assays to characterize the regulation pathways of miRNA-221 …
target genes by posttranscriptional regulation. miRNA-221 and miRNA-222 (miRNA-221/-
222) expression is elevated in radioresistant tumor cell lines; however, it is not known
whether and how miRNAs control cellular responses to ionizing irradiation. Methods and
Materials We used bioinformatic analyses, luciferase reporter assay, and genetic
knockdown and biochemical assays to characterize the regulation pathways of miRNA-221 …
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