MinK-related peptide 1: a β subunit for the HCN ion channel subunit family enhances expression and speeds activation

H Yu, J Wu, I Potapova, RT Wymore, B Holmes… - Circulation …, 2001 - Am Heart Assoc
H Yu, J Wu, I Potapova, RT Wymore, B Holmes, J Zuckerman, Z Pan, H Wang, W Shi…
Circulation research, 2001Am Heart Assoc
The HCN family of ion channel subunits underlies the currents I f in heart and I h and I q in
the nervous system. In the present study, we demonstrate that minK-related peptide 1
(MiRP1) is a β subunit for the HCN family. As such, it enhances protein and current
expression as well as accelerating the kinetics of activation. Because MiRP1 also functions
as a β subunit for the cardiac delayed rectifier I Kr, these results suggest that this peptide
may have the unique role of regulating both the inward and outward channels that underlie …
Abstract
—The HCN family of ion channel subunits underlies the currents If in heart and Ih and Iq in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a β subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a β subunit for the cardiac delayed rectifier IKr, these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.
Am Heart Assoc
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