… Having demonstrated that allogeneic ECs could trigger missing self-induced NK cell activation,
we sought to determine its impact on ECs. To this end, the integrity of adherent ECs was …

… that missing self and DSA can combine to induce chronic … involving NK cell is triggered
during chronic vascular rejection. … -γ pathway and NK cell-mediated cytotoxicity are upregulated …

… Recipient NK cells can also trigger antibody-… self HLA I–mediated inhibitory signals to
recipient’s NK cells (ie., MS) was sufficient to promote NK cell–mediated chronic vascular rejection. …

… are capable of triggering both antibody-… NK cells may contribute to MVI, which is NK cell
mediated but independent of the presence of alloantibody. In a cohort of 938 renal transplants …

… of DSA, missing self alone was sufficient to trigger NK cell-mediated chronic vascular rejection
35. In … rejection of solid organ transplants. Nat Commun 10: 5350, 2019 36. Haas M, Sis B, …

… , missing self’s clinical importance as a nonhumoral trigger of … prevention and treatment of T
cell–mediated rejection (TCMR). … , kidney transplantation after another solid organ transplant, …

… rejection (ABMR) remains one of the leading causes of allograft dysfunction and kidney
transplant … used to educate recipient NK cells, NK cells are activated, leading to chronic vascular …

… Missing self is triggered by a loss of HLA class I molecules, which normally act as inhibitory
… Missing self triggers NK cellmediated chronic vascular rejection of solid organ transplants. …

… of natural killer (NK) cells in allograft rejection. Methods. We explored associations of missing
self … On assessing the causes of individual graft losses, we found no consistent diagnosis, …

… missing self was sufficient to activate purified human NK cells in … -I on the graft vasculature
triggered NK cell activation, which … of missing self triggers activation of the recipient’s NK cells, …