Mitochondrial NADH kinase, Pos5p, is required for efficient iron-sulfur cluster biogenesis in Saccharomyces cerevisiae
J Pain, MM Balamurali, A Dancis, D Pain - Journal of Biological Chemistry, 2010 - ASBMB
In Saccharomyces cerevisiae, the mitochondrial inner membrane readily allows transport of
cytosolic NAD+, but not NADPH, to the matrix. Pos5p is the only known NADH kinase in the
mitochondrial matrix. The enzyme phosphorylates NADH to NADPH and is the major source
of NADPH in the matrix. The importance of mitochondrial NADPH for cellular physiology is
underscored by the phenotypes of the Δpos5 mutant, characterized by oxidative stress
sensitivity and iron-sulfur (Fe-S) cluster deficiency. Fe-S clusters are essential cofactors of …
cytosolic NAD+, but not NADPH, to the matrix. Pos5p is the only known NADH kinase in the
mitochondrial matrix. The enzyme phosphorylates NADH to NADPH and is the major source
of NADPH in the matrix. The importance of mitochondrial NADPH for cellular physiology is
underscored by the phenotypes of the Δpos5 mutant, characterized by oxidative stress
sensitivity and iron-sulfur (Fe-S) cluster deficiency. Fe-S clusters are essential cofactors of …
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