The role of mitochondria as a nexus of developmental regulation in mammalian oogenesis
and early embryogenesis is emerging from basic research in model species and from
clinical studies in infertility treatments that require in vitro fertilization and embryo culture.
Here, mitochondrial bioenergetic activities and roles in calcium homeostasis, regulation of
cytoplasmic redox state, and signal transduction are discussed with respect to outcome in
general, and as possible etiologies of chromosomal defects, maturation and fertilization …