Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals
R Pamplona, M Portero-Otin, D Riba, C Ruiz… - Journal of Lipid …, 1998 - ASBMB
The oxidative stress theory of aging predicts a low degree of fatty acid unsaturation in
tissues of longevous animals, because membrane lipids increase their sensitivity to
oxidative damage as a function of their unsaturation. Accordingly, the fatty acids analyses of
liver mitochondria from eight mammals, ranging in maximum life span from 3.5 to 46 years,
show that the total number of double bonds and the peroxidizability index are negatively
correlated with maximum life span (r=− 0. 88, P< 0.003; r=− 0.87, P< 0.004, respectively) …
tissues of longevous animals, because membrane lipids increase their sensitivity to
oxidative damage as a function of their unsaturation. Accordingly, the fatty acids analyses of
liver mitochondria from eight mammals, ranging in maximum life span from 3.5 to 46 years,
show that the total number of double bonds and the peroxidizability index are negatively
correlated with maximum life span (r=− 0. 88, P< 0.003; r=− 0.87, P< 0.004, respectively) …
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