Mitogenicity of the earthworm's (Eisenia foetida) insulin-like proteins.
M Hrzenjak, D Kobrehel, S Levanat, M Jurin… - … and physiology. B …, 1993 - europepmc.org
M Hrzenjak, D Kobrehel, S Levanat, M Jurin, T Hrzenjak
Comparative biochemistry and physiology. B, Comparative Biochemistry, 1993•europepmc.org1. Biologically active glycolipoprotein complex (G-90), isolated from whole earthworm tissue
extract (Eisenia foetida), was separated into seven fractions by gel-filtration. 2. It has been
shown by radioimmunoassay that each of the fractions, except the lightest one, is cross-
reactive with porcine anti-insulin antibodies. Molecules that possess such activity were
detected by immunoblotting. 3. All fractions, except the heaviest and the lightest one,
stimulate mammalian normal and transformed cell proliferation in serum-free conditions in …
extract (Eisenia foetida), was separated into seven fractions by gel-filtration. 2. It has been
shown by radioimmunoassay that each of the fractions, except the lightest one, is cross-
reactive with porcine anti-insulin antibodies. Molecules that possess such activity were
detected by immunoblotting. 3. All fractions, except the heaviest and the lightest one,
stimulate mammalian normal and transformed cell proliferation in serum-free conditions in …
1. Biologically active glycolipoprotein complex (G-90), isolated from whole earthworm tissue extract (Eisenia foetida), was separated into seven fractions by gel-filtration. 2. It has been shown by radioimmunoassay that each of the fractions, except the lightest one, is cross-reactive with porcine anti-insulin antibodies. Molecules that possess such activity were detected by immunoblotting. 3. All fractions, except the heaviest and the lightest one, stimulate mammalian normal and transformed cell proliferation in serum-free conditions in vitro. The intensity of stimulation depends on cell type. Stimulation is completely abolished if the medium is supplemented with fetal calf serum.
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