Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology
Introduction The cytoprotective PTEN‐induced kinase 1 (PINK1)‐parkin RBR E3 ubiquitin
protein ligase (PRKN) pathway selectively labels damaged mitochondria with
phosphorylated ubiquitin (pS65‐Ub) for their autophagic removal (mitophagy). Because
dysfunctions of mitochondria and degradation pathways are early features of Alzheimer's
disease (AD), mitophagy impairments may contribute to the pathogenesis. Methods
Morphology, levels, and distribution of the mitophagy tag pS65‐Ub were evaluated by …
protein ligase (PRKN) pathway selectively labels damaged mitochondria with
phosphorylated ubiquitin (pS65‐Ub) for their autophagic removal (mitophagy). Because
dysfunctions of mitochondria and degradation pathways are early features of Alzheimer's
disease (AD), mitophagy impairments may contribute to the pathogenesis. Methods
Morphology, levels, and distribution of the mitophagy tag pS65‐Ub were evaluated by …
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