A mode-dependent embedded-process-zone (EPZ) model has been developed and used to simulate the mixed-mode fracture of plastically deforming adhesive joints. Mode-I and mode-II fracture parameters obtained from previous work have been combined with a mixed-mode failure criterion to provide quantitative predictions of the deformation and fracture of mixed-mode geometries. These numerical calculations have been shown to provide excellent quantitative predictions for two geometries that undergo large-scale plastic deformation: asymmetric T-peel specimens and single lap-shear joints. Details of the deformed shapes, loads, displacements and crack propagation have all been captured reasonably well by the calculations.