Modeling regulation of vascular tone following muscle contraction: Model development, validation and global sensitivity analysis
JMT Keijsers, CAD Leguy, AJ Narracott… - Journal of computational …, 2018 - Elsevier
In this study the regulation of vascular tone inducing the blood flow increase at the onset of
exercise is examined. Therefore, our calf circulation model was extended with a regulation
model to simulate changes in vascular tone depending on myogenic, metabolic and
baroreflex regulation. The simulated blood flow corresponded to the in vivo response and it
was concluded that metabolic activation caused the flow increase shortly after muscle
contraction. Secondly, the change in baseline flow upon tilt was a result of myogenic and …
exercise is examined. Therefore, our calf circulation model was extended with a regulation
model to simulate changes in vascular tone depending on myogenic, metabolic and
baroreflex regulation. The simulated blood flow corresponded to the in vivo response and it
was concluded that metabolic activation caused the flow increase shortly after muscle
contraction. Secondly, the change in baseline flow upon tilt was a result of myogenic and …
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