Modular design of picroside-II biosynthesis deciphered through NGS transcriptomes and metabolic intermediates analysis in naturally variant chemotypes of a …
Picroside-II (P-II), an iridoid glycoside, is used as an active ingredient of various commercial
herbal formulations available for the treatment of liver ailments. Despite this, the knowledge
of P-II biosynthesis remains scarce owing to its negligence in Picrorhiza kurroa shoots which
sets constant barrier for function validation experiments. In this study, we utilized natural
variation for P-II content in stolon tissues of different P. kurroa accessions and deciphered its
metabolic route by integrating metabolomics of intermediates with differential NGS …
herbal formulations available for the treatment of liver ailments. Despite this, the knowledge
of P-II biosynthesis remains scarce owing to its negligence in Picrorhiza kurroa shoots which
sets constant barrier for function validation experiments. In this study, we utilized natural
variation for P-II content in stolon tissues of different P. kurroa accessions and deciphered its
metabolic route by integrating metabolomics of intermediates with differential NGS …
Modular design of picroside-II biosynthesis deciphered through NGS transcriptomes and metabolic intermediates analysis in naturally variant chemotypes of a …
VK Varun Kumar, AB Ankush Bansal, RS Chauhan - 2017 - cabidigitallibrary.org
Abstract Picroside-II (P-II), an iridoid glycoside, is used as an active ingredient of various
commercial herbal formulations available for the treatment of liver ailments. Despite this, the
knowledge of P-II biosynthesis remains scarce owing to its negligence in Picrorhiza kurroa
shoots which sets constant barrier for function validation experiments. In this study, we
utilized natural variation for P-II content in stolon tissues of different P. kurroa accessions
and deciphered its metabolic route by integrating metabolomics of intermediates with …
commercial herbal formulations available for the treatment of liver ailments. Despite this, the
knowledge of P-II biosynthesis remains scarce owing to its negligence in Picrorhiza kurroa
shoots which sets constant barrier for function validation experiments. In this study, we
utilized natural variation for P-II content in stolon tissues of different P. kurroa accessions
and deciphered its metabolic route by integrating metabolomics of intermediates with …
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