Modulation of STAT1 protein levels: a mechanism shaping CD8 T-cell responses in vivo
MP Gil, R Salomon, J Louten, CA Biron - Blood, 2006 - ashpublications.org
Type 1 interferons (IFNs) are induced in vivo, administered therapeutically, and potential
targets for amelioration of autoimmune diseases. The cytokines mediate profound
antiproliferative effects. Signal transducer and activator of transcription 1 (STAT1)-
dependent signaling pathways are required for inhibition of proliferation, and viral infections
can elicit high levels of type 1 IFNs as well as total STAT1 protein expression. Thus, a
mechanism must be in place to help antigen-specific T cells overcome IFN-induced …
targets for amelioration of autoimmune diseases. The cytokines mediate profound
antiproliferative effects. Signal transducer and activator of transcription 1 (STAT1)-
dependent signaling pathways are required for inhibition of proliferation, and viral infections
can elicit high levels of type 1 IFNs as well as total STAT1 protein expression. Thus, a
mechanism must be in place to help antigen-specific T cells overcome IFN-induced …
[引用][C] Modulation of STAT1 protein levels: a mechanism shaping CD8 T-cell responses invivo
E DURBIN, M PILAR GIL, R SALOMON, J LOUTEN… - Blood, 2006 - pascal-francis.inist.fr
Modulation of STAT1 protein levels : a mechanism shaping CD8 T-cell responses invivo …
Modulation of the immune response (stimulation, suppression) … Sauf mention contraire ci-dessus,
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antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una …
Modulation of the immune response (stimulation, suppression) … Sauf mention contraire ci-dessus,
le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC
BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record
may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado
antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una …