Aims/hypothesis A high-fat dietary intake induces obesity and subclinical inflammation,
which play important roles in insulin resistance. Recent studies have suggested that
increased concentrations of circulating lipopolysaccharide (LPS), promoted by changes in
intestinal permeability, may have a pivotal role in insulin resistance. Thus, we investigated
the effect of gut microbiota modulation on insulin resistance and macrophage infiltration.
Methods Swiss mice were submitted to a high-fat diet with antibiotics or pair-feeding for 8 …

A high-fat dietary intake induces obesity and subclinical inflammation, which play important
roles in insulin resistance. Recent studies have suggested that increased concentrations of
circulating lipopolysaccharide (LPS), promoted by changes in intestinal permeability, may
have a pivotal role in...