To evaluate the association of human leukocyte antigen (HLA)–DRB1 alleles with systemic
lupus erythematosus (SLE) and lupus nephritis (LN) in the Taiwanese population, and to
investigate the possible association of HLA-DRB1 alleles with disease severity in LN. HLA-
DRB1 alleles were studied in 105 SLE patients (82 patients with LN, 23 patients without LN)
and 855 healthy controls by polymerase chain reaction and sequence-based typing assays.
The frequency of the HLA class II alleles DRB1* 0301 (Odds ratio [OR]= 2.01, 95 …

SLE is an autoimmune disease characterized by multiple inflammation and production of
autoantibodies to a range of intracellular antigens involved in gene transcription and
translation. Genetic factors are likely to be important in both determining the overall
susceptibility to SLE and in influencing remarkable clinical heterogeneity in disease
expression observed between affected individuals (DCruzet al. 2007). The more common
clinical features seen in SLE patients include, skin and joint involvement's, renal …