Molecular glue concept solidifies
K Baek, BA Schulman - Nature chemical biology, 2020 - nature.com
… Molecular glues, first described for plant hormones such as auxin, gluing together E3 ligase
… , E7820, and tasisulum act as molecular glues now provide structural and mechanistic …
… , E7820, and tasisulum act as molecular glues now provide structural and mechanistic …
[PDF][PDF] Haven't got a glue: protein surface variation for the design of molecular glue degraders
… Molecular glue degraders are small, drug-like compounds … compounds already work as
molecular glue degraders, with … , with a focus on molecular glues hijacking cullin-RING ubiquitin …
molecular glue degraders, with … , with a focus on molecular glues hijacking cullin-RING ubiquitin …
Molecular glue degraders: exciting opportunities for novel drug discovery
T Lemaitre, M Cornu, F Schwalen, M Since… - Expert Opinion on …, 2024 - Taylor & Francis
… Molecular Glue Degraders (MGDs) is a concept that refers to a class of compounds that
facilitate the interaction between two proteins or molecules within a cell. These compounds act …
facilitate the interaction between two proteins or molecules within a cell. These compounds act …
Novel mechanisms of molecular glue-induced protein degradation
S Alabi - Biochemistry, 2021 - ACS Publications
… and structural studies to further solidify the proposed mechanism. … concepts to develop
molecular glue degraders with new functions, but there is still much to be learned. Small molecule …
molecular glue degraders with new functions, but there is still much to be learned. Small molecule …
[HTML][HTML] Screening for molecular glues–challenges and opportunities
GA Holdgate, C Bardelle, SK Berry, A Lanne… - SLAS Discovery, 2023 - Elsevier
… Molecular glues are small molecules, typically smaller than PROTACs, and usually with …
molecular glues and introduce approaches that could be adapted for molecular glue screening. …
molecular glues and introduce approaches that could be adapted for molecular glue screening. …
Discovery of Novel Molecular Glues and Targeted Protein Degradation Mechanisms for Cancer Therapeutics
YD Li - 2023 - search.proquest.com
… and characterize novel molecular glue and targeted protein … -based covalent BRD4 molecular
glue degraders and their … substrate receptor independent molecular glue degrader CR8, …
glue degraders and their … substrate receptor independent molecular glue degrader CR8, …
Molecular glues targeting protein degradation pathways for drug discovery
C Ren, X Gan, H Zhou, J Li, J Zhang - Future Medicinal Chemistry, 2022 - Future Science
… molecular glues have been satisfactory, molecular glues are very much scant. A systematic
discovery and design strategy for molecular glues … binding model of molecular glue-induced …
discovery and design strategy for molecular glues … binding model of molecular glue-induced …
Ultra-strong bio-glue from genetically engineered polypeptides
… The development of biomedical glues is an important, yet … adhesive as biomedical glue
outperforming some commercial … We demonstrate the glue’s robust performance in vitro and in …
outperforming some commercial … We demonstrate the glue’s robust performance in vitro and in …
Synthesis of robust underwater glues from common proteins via unfolding-aggregating strategy
Y Liu, K Li, J Tian, A Gao, L Tian, H Su, S Miao… - Nature …, 2023 - nature.com
… (DMA) of the solidified BSA glue showed that the storage … network structure inside the solidified
BSA glue. The existence … of the solidified glue, since the volume of the solidified BSA glue …
BSA glue. The existence … of the solidified glue, since the volume of the solidified BSA glue …
Water‐Triggered Spontaneously Solidified Adhesive: From Instant and Strong Underwater Adhesion to In Situ Signal Transmission
… The resulting glue is solidified into a white sticky gum instantly after … The solidified glue is
no longer flowing, and the shape of “ZJUT” sketched onto underwater glass surface with glue …
no longer flowing, and the shape of “ZJUT” sketched onto underwater glass surface with glue …
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