Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators
EM Rothweiler, PE Brennan, KVM Huber - Biological Chemistry, 2022 - degruyter.com
… Pharmacological exploitation of this phenomenon via targeted protein degradation (TPD)
can be achieved with molecular glues or bifunctional molecules facilitating the formation of …
can be achieved with molecular glues or bifunctional molecules facilitating the formation of …
PPI-Miner: A Structure and Sequence Motif Co-Driven Protein–Protein Interaction Mining and Modeling Computational Method
… KC1A, IKZF1, IKZF2, and ERF3A were selected to extract the structurally conserved CRBN
binding motifs, and the thalidomide was colored magenta to represent the molecular glue. …
binding motifs, and the thalidomide was colored magenta to represent the molecular glue. …
Proximity‐Inducing Bifunctional Molecules Beyond PROTACs
S Lai, AE Modell, A Choudhary - Protein Homeostasis in Drug …, 2022 - Wiley Online Library
… help of small molecules as mediators of proximity, and examples of natural products such
as the plant hormone auxin act as chemical inducers of proximity (ie a molecular glue) have …
as the plant hormone auxin act as chemical inducers of proximity (ie a molecular glue) have …
Biological and biomimetic adhesives: challenges and opportunities
… sticky complex coacervate that further solidifies via DOPA crosslinking. Synthetic … glue setting.
It does not affect the solubility or stiffness of mature glues, but when it is present as the glue …
It does not affect the solubility or stiffness of mature glues, but when it is present as the glue …
Manipulatives help to teach molecular diagnostic concepts
AE Hentzen - Laboratory Medicine, 2000 - academic.oup.com
… We then glued these molecular weight marker Popsicle sticks to a 44 3 88-cm piece of white
… In our study, manipulatives helped students to solidify concepts through visualizing and …
… In our study, manipulatives helped students to solidify concepts through visualizing and …
Identification of potent, selective, and orally bioavailable small-molecule GSPT1/2 degraders from a focused library of cereblon modulators
G Nishiguchi, F Keramatnia, J Min… - Journal of medicinal …, 2021 - ACS Publications
… ” molecular glues providing the mechanistic and clinical validation of this approach. (7,11) …
In this fashion, we synthesized a molecular glue library (MGL) of 415 compounds containing …
In this fashion, we synthesized a molecular glue library (MGL) of 415 compounds containing …
Superstructures of functional colloids: chemistry on the nanometer scale
M Antonietti, C Göltner - Angewandte Chemie International …, 1997 - Wiley Online Library
… Polymerization in microemulsions utilizes these droplets as casting molds by solidifying their
… This “molecular glue”, which attaches the two other (functional or structural) components to …
… This “molecular glue”, which attaches the two other (functional or structural) components to …
Switchable adhesion: on‐demand bonding and debonding
Z Liu, F Yan - Advanced Science, 2022 - Wiley Online Library
… drying glue in 1957, which we use today. [ 5 ] Environmental concerns made hot melt glue
… P1, with a melting point of 52 C, is a very viscous liquid that rapidly solidifies upon cooling. It …
… P1, with a melting point of 52 C, is a very viscous liquid that rapidly solidifies upon cooling. It …
Solidifying cathode–electrolyte interface for lithium–sulfur batteries
WP Wang, J Zhang, J Chou, YX Yin… - Advanced Energy …, 2021 - Wiley Online Library
… the strategies for realizing solidified cathode–electrolyte interface … species at various types
of solidified interfaces, will be discussed … accompanied with the solidified interface will also be …
of solidified interfaces, will be discussed … accompanied with the solidified interface will also be …
Targeted degradation of immune checkpoint proteins: emerging strategies for cancer immunotherapy
… Molecular glues, initially reported as plant hormones that glue a transcription factor to … of
certain proteins by acting as a molecular glue. It was discovered that thalidomide and some …
certain proteins by acting as a molecular glue. It was discovered that thalidomide and some …