… been made in understanding the molecular mechanisms whereby primary sensory neurons
detect pain-producing stimuli, a process referred to as nociception. These insights have …

Publisher Summary This chapter reviews that the cataloging of the key molecules involved
in nociceptive signal transduction and the setting of peripheral pain thresholds has been …

… The aim of this review is to highlight the molecular mechanisms involved in pain initiation in
… Each molecular mechanism of nociceptive signaling, whether in the primary sensory neuron, …

… Getting insights into nociceptive processes will lead to a better understanding of chronic …
of nociceptive mechanisms, from the periphery to the brain, proposing new mechanisms and…

… a light touch in other body areas might mediate nociception in teeth. Elucidation of the
differential molecular mechanisms underlying nociception in teeth will provide an invaluable basis …

… Genetic, electrophysiological, and pharmacological studies are elucidating the molecular
mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate …

… Understanding such mechanisms is critical for developing … molecular mechanisms that
may contribute to nociception in … review focusing on the molecular mechanisms of MC-mediated …

Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of the …

TRPV1 is a polymodally activated cation channel acting as key receptor in nociceptive
neurons. Its function is strongly affected by kinase-mediated phosphorylation leading to …

… Thus, TRPV1 is a central molecule for detecting nociceptive stimuli. … Capsiate injection into
a hindpaw induced nociceptive behavior but failed to induce classical signs of irritation when …