Molecular monitoring of residual disease in chronic myelogenous leukemia patients after therapy

R Haas, R Kronenwett, G Sczakiel, A Hochhaus… - … and Molecular Therapy, 1998 - Springer
… reduced considerably if patients are monitored by molecular … , or competitive reverse
transcriptase polymerase chain reaction (… trial of interferon-alpha n 1 for chronic myeloid

Chronic myelocytic leukemia–part II: approaches to and molecular monitoring of therapy

TR Randolph - American Society for Clinical Laboratory Science, 2005 - clsjournal.ascls.org
Competitive or real-time quantitative reverse transcriptase … in CML patients in complete
remission after interferon-alpha … transcriptase-polymerase chain reaction predicts outcome after …

Molecular monitoring of chronic myeloid leukemia

T Hughes, S Branford - Seminars in hematology, 2003 - Elsevier
… and lower progression rates than interferon-alpha. However, … (FISH) and qualitative
polymerase chain reaction (PCR) have … The level of BCR-ABL measured by competitive Q-PCR is …

Re-emergence of interferon-α in the treatment of chronic myeloid leukemia

M Talpaz, R Hehlmann, A Quintas-Cardama, J Mercer… - Leukemia, 2013 - nature.com
polymerase chain reaction (PCR) and found that patients who … continuously monitored
BCR-ABL transcript levels by RT–… -positive chronic myelogenous leukemia with interferon-alpha

Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon α/ara-C

MC Müller, N Gattermann, T Lahaye, MWN Deininger… - Leukemia, 2003 - nature.com
… response of CML patients treated with interferon-alpha monitored by … in chronic myelogenous
leukemia patients on interferon-alpha therapy by competitive polymerase chain reaction. …

Molecular diagnosis and monitoring in the clinical management of patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors

J Ou, JA Vergilio, A Bagg - American journal of hematology, 2008 - Wiley Online Library
… reverse transcriptasepolymerase chain reaction analyses (RT-… pharmacological agents such
as interferon alpha (with or … from the initial use of competitive and limiting dilution RT-PCR …

Molecular monitoring of response to imatinib (Glivec®) in CML patients pretreated with interferon alpha. Low levels of residual disease are associated with continuous …

P Paschka, MC Müller, K Merx, S Kreil, C Schoch… - Leukemia, 2003 - nature.com
… of individual patients to treatment or to evaluate the efficacy of a particular … in chronic
myelogenous leukemia patients on interferon-α therapy by competitive polymerase chain reaction. …

Practical monitoring of chronic myelogenous leukemia: when to change treatment

G Saglio, C Fava - Journal of the National Comprehensive Cancer …, 2012 - jnccn.org
… real-time quantitative polymerase chain reaction (RQ-PCR) … , whose efficacy as second-line
therapy in patients with imatinib-… of any products discussed in this article or their competitors. …

A guide to the use of interferon-alpha in the management of chronic myelogenous leukaemia

J Cortes, S O'Brien - BioDrugs, 2000 - Springer
Patients should be monitored closely with cytogenetic and possibly other analyses such as
fluorescent in situ hybridisation (FISH) and polymerase chain reaction (… Although the efficacy

Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-α therapy

…, S Pierce, M Talpaz, Leukemia Service* - Annals of Internal …, 1995 - acpjournals.org
therapy in chronic myelogenous leukemia were initiated by our group in 1982. Since then,
several trials [8-12] have confirmed its efficacy … (ICSG-CML), patients were randomly assigned …