MONITORING OF BUFFY COAT THERAPY IN CHRONIC MYELOGENOUS LEUKEMIA (CML) WITH QUANTITA TIVE POLYMERASE CHAIN REACTION (PCR)

SNM Schmidt, ULDHW Siegert, A Neubauer - karger.com
… and efficiently detected after reverse transcription into cDNA by … Coamplification did not
show any competition between the … Most patients (n=26) were on interferon alpha (a-IFN) or …

… response and course of chronic myeloid leukemia in the modern era of BCR-ABL tyrosine kinase inhibitors: practical advice on the use and interpretation of monitoring …

H Kantarjian, C Schiffer, D Jones… - Blood, The Journal of …, 2008 - ashpublications.org
effectiveness of initial therapy; (2) monitoring for treatment … qualitative and quantitative
polymerase chain reaction (QPCR)… with improved long-term survival with interferon-alpha therapy. …

Expression of interferon-α (IFN-α) receptor 2c at diagnosis is associated with cytogenetic response in IFN-α–treated chronic myeloid leukemia

C Barthe, FX Mahon, MJ Gharbi… - Blood, The Journal …, 2001 - ashpublications.org
… the response to interferon-alpha (IFN-α) treatment is important … In this study, real-time
quantitative polymerase chain reaction (q-… Chronic myelocytic leukemia: clonal origin in a stem cell …

Chronic myelocytic leukemia–part II: approaches to and molecular monitoring of therapy

TR Randolph - American Society for Clinical Laboratory Science, 2005 - clsjournal.ascls.org
Competitive or real-time quantitative reverse transcriptase … in CML patients in complete
remission after interferon-alpha … transcriptase-polymerase chain reaction predicts outcome after …

Serial monitoring of BCR-ABL transcripts in chronic myelogenous leukemia (CML) treated with imatinib mesylate

M Hardling, Y Wei, L Palmqvist, B Swolin… - Medical oncology, 2004 - Springer
… information about the efficiency of therapy, especially in patients with a … chronic myelogenous
leukemia patients on interferon-alpha therapy by competitive polymerase chain reaction

Monitoring treatment of chronic myeloid leukemia

M Baccarani, F Pane, G Saglio - Haematologica, 2008 - haematologica.org
polymerase chain reaction (RT-PCR) in the follow-up of CML … and to monitor the
response.27,28 However, the competitive … with high-quality performance characteristics will …

Quantitative competitive reverse transcriptase-polymerase chain reaction for BCR-ABL on Philadelphia-negative leukaphereses allows the selection of low …

MT Corsetti, E Lerma, A Dejana, P Basta, R Ferrara… - Leukemia, 1999 - nature.com
monitored the leukemic cells with a quantitative-competitive … This change did not have
any effect on the efficiency of our … chronic myelogenous leukemia patients on interferon-alpha

Expression of interferon regulatory factor (IRF) genes and response to interferon-α in chronic myeloid leukaemia

A Hochhaus, XH Yan, A Willer, R Hehlmann… - Leukemia, 1997 - nature.com
Interferon-alpha overrides the deficient adhesion of … polymerase chain reaction (PCR) for
detection of BCR-ABL fusion … Quantification of residual disease in chronic myelogenous leuke- …

Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon α/ara-C

MC Müller, N Gattermann, T Lahaye, MWN Deininger… - Leukemia, 2003 - nature.com
… response of CML patients treated with interferon-alpha monitored by … in chronic myelogenous
leukemia patients on interferon-alpha therapy by competitive polymerase chain reaction. …

Detection and quantification of residual disease in chronic myelogenous leukemia

A Hochhaus, A Weisser, P La Rosee, M Emig… - Leukemia, 2000 - nature.com
… of qualitative PCR for monitoring CML patients after therapy, quantitative BCR-… competitive
PCR strategies that can effectively control for variations in amplification efficiency and reaction