… , the reverse-transcriptase polymerase chain reaction (RT-… In the early 1990s a number of
groups developed competitive … of interferon-alpha in the treatment of chronic myeloid leukemia…

… information about the efficiency of therapy, especially in patients with a … chronic myelogenous
leukemia patients on interferon-alpha therapy by competitive polymerase chain reaction…

… -time quantitative polymerase chain reaction assessments of … molecular responses and
mutation monitoring. The aim of … (DASISION) demonstrated improved efficacy versus imatinib at …

… was to evaluate the efficacy of a treatment protocol and to … patients were pretreated with
busulfan or interferon-alpha, … A hypothetical mechanism could be competition with IM for a …

… reverse-transcriptase polymerase chain reaction (PCR) has allowed patients in complete …
RNA and for differences in the efficiency of the reverse-transcriptase reaction. Nested PCR …

… dose schedules with monitoring of the white cell count. … It acts as a competitive inhibitor
of the ATP binding site on the … efficacy of an indigenous recombinant interferon-alpha-2b in …

… and efficiently detected after reverse transcription into cDNA by … Coamplification did not
show any competition between the … Most patients (n=26) were on interferon alpha (a-IFN) or …

… their resistance to interferon-alpha or tyrosine kinase inhibitors. … in liquid culture or plating
efficiency in semisolid culture medium (… monitoring of residual disease in chronic myelogenous …

… were established for patients on interferon alpha. They have … the competitive PCR assays
for monitoring treatment response, … chromosome-positive chronic myelogenous leukemia: high …

… -polymerase chain reaction (Q-RT-PCR) methods to study minimal residual disease in 3
patients with CML in … After treatment with IFN-α or allogeneic BMT, the monitoring of the residual …