Monoclonal gammopathy: The good, the bad and the ugly
Monoclonal gammopathy of undetermined significance (MGUS) is a condition characterized
by the presence of a monoclonal gammopathy (MG) in which the clonal mass has not
reached a predefined state in which the condition is considered malignant. It is a precursor
to conditions such as multiple myeloma or lymphoma at a rate of~ 1%/year. Thus, from a
hematologic standpoint, MGUS is a fairly benign condition. However, it is now recognized
that organ damage resulting from just the MG without the need MM or lymphoma can occur …
by the presence of a monoclonal gammopathy (MG) in which the clonal mass has not
reached a predefined state in which the condition is considered malignant. It is a precursor
to conditions such as multiple myeloma or lymphoma at a rate of~ 1%/year. Thus, from a
hematologic standpoint, MGUS is a fairly benign condition. However, it is now recognized
that organ damage resulting from just the MG without the need MM or lymphoma can occur …
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