… cause or even predict human nephropathy and its … diabetic nephropathy is the lack of
reliable animal models that mimic human disease. Hence, in 2001, the Animal Models of Diabetic …

… in mice (including knockouts and transgenics), the validation of a mouse model reproducing
… Establishment of an authentic mouse model of DN will undoubtedly facilitate testing of …

… The db/db mouse model of leptin deficiency is currently the most widely used mouse for
modeling diabetic nephropathy in settings of Type II diabetes. Leptin deficiency confers …

… and can be used to study not only the natural history of diabetic nephropathy, but also to …
diabetic nephropathy. These different genetic models of diabetic nephropathy in the mouse are …

… to the induction of diabetes and are … diabetic nephropathy studies performed on mice with
a C57BL/6 genetic background. Recent information on diabetic nephropathy in other mouse …

… Here, we discuss the current status of mouse models for DN, their limitations and opportunities
for improvement. We emphasize that future efforts should focus on generating robust …

… susceptibility to diabetic nephropathy exist in mice based … mice model of diabetes is used
to study diabetic nephropathy, we must consider the genetic background and strain of the mice …

… for the researchers by creating a website that includes a protocol for validation of mouse
models of diabetic nephropathy and updated characterization of different diabetic models. …

… mouse models. The first principle to keep in mind is that none of the mouse models fully mimics
human diabetic nephropathy… the AMDCC researchers, several models that recapitulate at …

… Some studies on mouse models of DN show that high-dose STZ-treated mice exhibit
more albuminuria than those which receive low-dose STZ, despite of similar blood glucose [10]. …