Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells
VP Ramsauer, CAC Carraway, PJI Salas… - Journal of Biological …, 2003 - ASBMB
Muc4/Sialomucin complex (SMC) acts as an intramembrane ligand for the receptor tyrosine
kinase ErbB2, inducing a limited phosphorylation of the receptor. Because Muc4/SMC is
found at the apical surfaces of polarized epithelial cells and ErbB2 is often basolateral, the
question arises as to whether these components become associated in polarized cells. To
address this question, we examined the localization of these proteins in polarized human
colon carcinoma CACO-2 cells. Dual color immunofluorescence analysis by confocal …
kinase ErbB2, inducing a limited phosphorylation of the receptor. Because Muc4/SMC is
found at the apical surfaces of polarized epithelial cells and ErbB2 is often basolateral, the
question arises as to whether these components become associated in polarized cells. To
address this question, we examined the localization of these proteins in polarized human
colon carcinoma CACO-2 cells. Dual color immunofluorescence analysis by confocal …
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