With the expansion of the medical assistance scheme in 2012, the consumption of pharmaceutical products in the Moroccan public sector increased exponentially. Several assessments of the current supply chain of pharmaceutical products indicated the saturation of the logistical system and its inadequacy to the new challenges faced. The purpose of this paper is to elaborate a general approach to distribution network redesign. Based on prioritized criteria, such as supply chain responsiveness and costs, it allows comparing different distribution network designs and selecting the most appropriate one using AHP multi-criteria decision making method. This general approach is applied to the case study of the Moroccan pharmaceutical supply chain in the public sector.