Background The treatment of multidrug-resistant Acinetobacter baumannii meningitis is a
serious therapeutic problem due to the limited penetration of antibiotics into the CSF. We
describe the clinical features and the outcome of a group of patients with nosocomial
neurosurgical meningitis treated with different therapeutic options. Methods All patients with
nosocomial post-surgical meningitis due to A. baumannii diagnosed between 1990 and
2004 were retrospectively reviewed. Results During the period of study, 51 cases of this …

Sir, Post-surgical meningitis caused by MDR Acinetobacter baumannii continues to be a
serious problem owing to its high mortality and the limited therapeutic options, so combined
treatment with IV and intrathecal colistin is currently considered as the treatment of choice. 1,
2 Perez-Alba et al. 3 describe the treatment of nine patients treated with a combination of
high-dose meropenem and 20 mg every 24 h of intrathecal colistin. The study had to be
suspended owing to the appearance of convulsions in six patients, worsening on the …