We present MusikVerb, a novel digital reverberation capable of adapting its output to the harmonic context of a live music performance. The proposed reverberation is aware of the harmonic content of an audio input signal and ‘tunes’ the reverberation output to its harmonic content using a spectral filtering technique. The dynamic behavior of MusikVerb avoids the sonic clutter of traditional reverberation, and most importantly, fosters creative endeavor by providing new expressive and musically-aware uses of reverberation. Despite its applicability to any input audio signal, the proposed effect has been designed primarily as a guitar pedal effect and a standalone software application.