Mycobacterium tuberculosis EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages
Mycobacterium tuberculosis is known to modulate the host immune responses to facilitate its
persistence inside the host cells. One of the key mechanisms includes repression of class-II
transactivator (CIITA) and MHC-II expression in infected macrophages. However, the precise
mechanism of CIITA and MHC-II down-regulation is not well studied. M. tuberculosis 6-kDa
early secretory antigenic target (ESAT-6) is a known potent virulence and antigenic
determinant. The M. tuberculosis genome encodes 23 such ESAT-6 family proteins. We …
persistence inside the host cells. One of the key mechanisms includes repression of class-II
transactivator (CIITA) and MHC-II expression in infected macrophages. However, the precise
mechanism of CIITA and MHC-II down-regulation is not well studied. M. tuberculosis 6-kDa
early secretory antigenic target (ESAT-6) is a known potent virulence and antigenic
determinant. The M. tuberculosis genome encodes 23 such ESAT-6 family proteins. We …
Withdrawal: Mycobacterium tuberculosis EsxL inhibits MHC-II expression by promoting hypermethylation in class-II transactivator loci in macrophages
S Sengupta, S Naz, I Das, A Ahad, A Padhi… - Journal of Biological …, 2019 - ASBMB
Mycobacterium tuberculosis is known to modulate the host immune responses to facilitate its
persistence inside the host cells. One of the key mechanisms includes repression of class-II
transactivator (CIITA) and MHC-II expression in infected macrophages. However, the precise
mechanism of CIITA and MHC-II down-regulation is not well studied. M. tuberculosis 6-kDa
early secretory antigenic target (ESAT-6) is a known potent virulence and antigenic
determinant. The M. tuberculosis genome encodes 23 such ESAT-6 family proteins.
persistence inside the host cells. One of the key mechanisms includes repression of class-II
transactivator (CIITA) and MHC-II expression in infected macrophages. However, the precise
mechanism of CIITA and MHC-II down-regulation is not well studied. M. tuberculosis 6-kDa
early secretory antigenic target (ESAT-6) is a known potent virulence and antigenic
determinant. The M. tuberculosis genome encodes 23 such ESAT-6 family proteins.
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