Myocardial distribution of digoxin and renal function
WJ Jusko, M Weintraub - Clinical Pharmacology & …, 1974 - Wiley Online Library
WJ Jusko, M Weintraub
Clinical Pharmacology & Therapeutics, 1974•Wiley Online LibraryDigoxin concentmtions in serum and left ventricular tissue were measured at autopsy and
related to estimated antemortem creatinine clearances in 15 patients. A significant
correlation teas found between myocardium: serum concentmtion ratio of digoxin and
creatinine clearance. This phenomenon partly explains the large variability in tissue: serum
ratios of digoxin reported in the literature and is consistent with the relatively smaller
apparent volume of distribution of digoxin reported in patients with impaired renal function.
related to estimated antemortem creatinine clearances in 15 patients. A significant
correlation teas found between myocardium: serum concentmtion ratio of digoxin and
creatinine clearance. This phenomenon partly explains the large variability in tissue: serum
ratios of digoxin reported in the literature and is consistent with the relatively smaller
apparent volume of distribution of digoxin reported in patients with impaired renal function.
Digoxin concentmtions in serum and left ventricular tissue were measured at autopsy and related to estimated antemortem creatinine clearances in 15 patients. A significant correlation teas found between myocardium:serum concentmtion ratio of digoxin and creatinine clearance. This phenomenon partly explains the large variability in tissue:serum ratios of digoxin reported in the literature and is consistent with the relatively smaller apparent volume of distribution of digoxin reported in patients with impaired renal function.
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