… a catalytic metal in the process of metalloenzyme evolution is … metal selections may be
dictated by metal availability, as described in numerous examples of hydrolases. Alternate metal …

… /metalloenzymes are made of about 14 metal ions, and several types of metal complexes
(such as heme) or metal … limit the functionalities of native metalloenzymes. To overcome these …

… Our findings help reveal the complexity and diversity of metalloenzyme design, from modifying
the metal-coordination spheres to redesigning the secondary or tertiary protein structures. …

… The 22 different EC numbers present in the energetic nitrogen cycle on KEGG are
oxidoreductases, and 16 (73%) of them are metalloenzymes relevant in our context. The most …

… Natural metalloenzymes are often the most proficient catalysts in terms of … , metalloenzymes
are occasionally surprising in their choice of catalytic metals, and in their responses to metal …

… , such as availability of metals in the cell [1, 2]. On the contrary, a wider library of metals can
be used in metalloenzyme design, where the main … Mysteries of metals in metalloenzymes …

… Why metalloenzymes often show dramatic changes in their … metal substitutions is a
long-standing puzzle. Here, we report on the catalytic roles of metal ions in a model metalloenzyme …

… metal isoform. Our study suggests that promiscuous activities of metalloenzymes can stem
from an ensemble of metal … role of metal substitution for evolution of metalloenzymes toward …

… Transition metal elements are the leading players in metalloenzyme catalysis. Metal ions
govern … It forms noncovalent interactions with metal cofactors and substrates, resulting in their …

… The unique and adjustable electrochemical properties of metal ions make it … Natural transition
metal complexes such as metalloenzymes are well … Mysteries of metals in metalloenzymes …