The identification and characterization of molecular mechanisms utilized by cells to mediate
transcriptional repression at methylated loci are fundamental to understanding the biological
consequences of DNA methylation. Here we demonstrate that Kaiso, a methyl CpG binding
protein belonging to the BTB/POZ family of transcription factors, is a component of the
human N-CoR complex. In vitro, the Kaiso/N-CoR complex binds specific CpG-rich
sequences in a methylation-dependent manner. In vivo, Kaiso targets the N-CoR complex to …

N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding
protein Kaiso | CiNii Research … N-CoR mediates DNA methylation-dependent repression
through a methyl CpG binding protein Kaiso …