NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains
Neurotrophins initiate their biological effects by activating members of the trk tyrosine kinase
subfamily. The extracellular region of trk receptors is distinguished by several common
structural features, including leucine-rich repeats, clusters of cysteine-rich domains, and two
immunoglobulin-like domains. However, the receptor sequences required for ligand binding
have not been localized. In order to define the domains involved in NGF binding, a series of
chimeric receptors was constructed using cDNA sequences from rat trkA and trkB. The …
subfamily. The extracellular region of trk receptors is distinguished by several common
structural features, including leucine-rich repeats, clusters of cysteine-rich domains, and two
immunoglobulin-like domains. However, the receptor sequences required for ligand binding
have not been localized. In order to define the domains involved in NGF binding, a series of
chimeric receptors was constructed using cDNA sequences from rat trkA and trkB. The …
NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains
P Pérez González, PM Coll, BL Hempstead… - 1995 - digital.csic.es
Neurotrophins initiate their biological effects by activating members of the trk tyrosine kinase
subfamily. The extracellular region of trk receptors is distinguished by several common
structural features, including leucine-rich repeats, clusters of cysteine-rich domains, and two
immunoglobulin-like domains. However, the receptor sequences required for ligand binding
have not been localized. In order to define the domains involved in NGF binding, a series of
chimeric receptors was constructed using cDNA sequences from rat trkA and trkB. The …
subfamily. The extracellular region of trk receptors is distinguished by several common
structural features, including leucine-rich repeats, clusters of cysteine-rich domains, and two
immunoglobulin-like domains. However, the receptor sequences required for ligand binding
have not been localized. In order to define the domains involved in NGF binding, a series of
chimeric receptors was constructed using cDNA sequences from rat trkA and trkB. The …
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