[HTML][HTML] NLRP3 inflammasome deficiency attenuates cerebral ischemia-reperfusion injury by inhibiting ferroptosis

Z Wang, Y Li, Y Ye, H Zhu, J Zhang, H Wang, J Lei… - Brain research …, 2023 - Elsevier
Background The role of ferroptosis in ischemic stroke has been hotly debated recently, but
the mechanism is not clearly clarified. It has been reported that the NLRP3 inflammasome is
essential for the progression of ischemic stroke. Whether the ferroptosis after ischemic stroke
mediated by the activation of NLRP3 inflammasome is still not reported. In this study, we
investigated the effect of NLRP3 deficiency on ferroptosis following cerebral ischemia-
reperfusion injury (CIRI) in vivo and in vitro. Materials In vivo, we used C57BL/6J mice and …
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