Nanobowl-supported liposomes improve drug loading and delivery

ZJ Chen, SC Yang, XL Liu, Y Gao, X Dong, X Lai… - Nano Letters, 2020 - ACS Publications
Liposomal drug delivery for cancer therapy can be limited due to drug leakage in circulation.
Here, we develop a new method to enhance the stability of actively loaded liposomal
doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity.
Nanobowl-supported liposomal DOX (DOX@ NbLipo) resists the influence of plasma protein
and blood flow shear force to prevent drug leakage. This approach yields improved drug
delivery to tumor sites and enhanced antitumor efficacy. Compared to alternative methods of …

[PDF][PDF] Nanobowl-Supported Liposomes Improve Drug Loading and Delivery

C Fang - researchgate.net
Styrene, 3-trimethoxysilylpropyl methacrylate (MPS), sodium 4-vinylbenzenesulfonate
(VBS), tetraethyl orthosilicate (TEOS, 98%), N-(3-trimethoxysilylpropyl) diethylenetriamine,(3-
aminopropyl) triethoxysilane, and sulforhodamine B (SRB) were purchased from Sigma-
Aldrich (St. Louis, MO). Ammonium hydroxide solution (25% NH3), 2, 2'-azobis 2-
methylpropionitrile (AIBN), potassium peroxodisulfate (KPS), sodium dodecyl sulfate (SDS),
tetrahydrofuran (THF) and ammonium sulfate were purchased from J&K Scientific Company …
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