During the last couple of decades, nanodelivery system has taken an impetus in the field of nanopharmaceuticals not only because of their targeting potential but also for high bioavailability. Recently, nano‐formulations are being used combined with herbal extracts and a variety of phytochemicals. Plants and spices are the richest sources of phytochemicals such as polyphenols, alkaloids, and flavonoids that possess giant antioxidant properties. Therefore, dietary supplementation with bioactive phytochemicals having antioxidant and anti‐inflammatory activities is currently regarded as a promising therapeutic strategy to combat the disbalance of natural phenomena of the body. Nanodelivery systems such as nanoparticles, solid lipid nanoparticles, nano‐emulsion, micelles, liposomes, and carbon nanotubes (CNTs) can have much‐extended self‐life, improved stability, and solubility with superior permeability to improve the cell‐targeting capacity, and minimal toxicity. This chapter provides a brief overview of nanodelivery of plant products that hold antioxidant activity, the antioxidant mechanism, and problems associated with nano‐formulations encapsulating herbal extracts, spices, and dietary constituents, with patent and clinical trials data.