The local heat delivered by metallic nanoparticles selectively attached to their target can be
used as a molecular surgery to safely remove toxic and clogging aggregates. We apply this
principle to protein aggregates, in particular to the amyloid beta protein (Aβ) involved in
Alzheimer's disease (AD), a neurodegenerative disease where unnaturally folded Aβ
proteins self-assemble and deposit forming amyloid fibrils and plaques. We show the
possibility to remotely redissolve these deposits and to interfere with their growth, using the …

The local heat delivered by metallic nanoparticles selectively attached to their target can be
used as a molecular surgery to safely remove toxic and clogging aggregates. We apply this
principle to protein aggregates, in particular to the amyloid beta protein (A beta) involved in
Alzheimer's disease (AD), a neurodegenerative disease where unnaturally folded A beta
proteins self-assemble and deposit forming amyloid fibrils and plaques. We show the
possibility to remotely redissolve these deposits and to interfere with their growth, using the …