[HTML][HTML] Near infrared photoimmunotherapy for cancers: A translational perspective
Y Maruoka, H Wakiyama, PL Choyke, H Kobayashi - EBioMedicine, 2021 - thelancet.com
Near-infrared photoimmunotherapy (NIR-PIT) is a newly-developed, highly-selective cancer
treatment, which utilizes a monoclonal antibody conjugated to a photoabsorbing dye,
IRDye700DX (IR700). The antibody conjugate is injected into the patient and accumulates in
the tumour. Within 24 h of injection the tumour is exposed to NIR light which activates the
conjugate and causes rapid, selective cancer cell death. A global phase III clinical trial of
NIR-PIT in recurrent head and neck squamous cell cancer (HNSCC) patients is currently …
treatment, which utilizes a monoclonal antibody conjugated to a photoabsorbing dye,
IRDye700DX (IR700). The antibody conjugate is injected into the patient and accumulates in
the tumour. Within 24 h of injection the tumour is exposed to NIR light which activates the
conjugate and causes rapid, selective cancer cell death. A global phase III clinical trial of
NIR-PIT in recurrent head and neck squamous cell cancer (HNSCC) patients is currently …
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