The role of autophagy in neurodegenerative disease

RA Nixon - Nature medicine, 2013 - nature.com
… regulating autophagy cause neurodegenerative diseasesdisease, amyotrophic lateral
sclerosis and familial Parkinson's disease, defects arise at different stages of the autophagy

Compromised autophagy and neurodegenerative diseases

FM Menzies, A Fleming, DC Rubinsztein - Nature Reviews …, 2015 - nature.com
… , autophagy dysfunction has also been implicated in the pathogenesis of various diseases.
… of how perturbations in autophagy are linked with neurodegenerative diseases and the …

Autophagy gone awry in neurodegenerative diseases

E Wong, AM Cuervo - Nature neuroscience, 2010 - nature.com
… as the nature of the autophagic defect in different neurodegenerative disorders, are now …
autophagic dysfunction in neurodegeneration and the importance of identifying the autophagic

Autophagy in neurodegenerative diseases: pathogenesis and therapy

F Guo, X Liu, H Cai, W Le - Brain pathology, 2018 - Wiley Online Library
diseases and neurodegenerative diseases 17, 47, 78. Many studies have shown … autophagy
is closely linked with neurodegenerative diseases. For example, the amount of autophagic

Control of autophagy as a therapy for neurodegenerative disease

H Harris, DC Rubinsztein - Nature reviews neurology, 2012 - nature.com
… Pharmacological induction of autophagy can enhance the clearance of intracytoplasmic …
animal models of neurodegenerative diseases. In this Review, the autophagic machinery and …

Association between autophagy and neurodegenerative diseases

N Fujikake, M Shin, S Shimizu - Frontiers in neuroscience, 2018 - frontiersin.org
… Next, we review how autophagy is involved in the pathology of several neurodegenerative
diseases. We also summarize the therapeutic effects of autophagy-modulating compounds on …

The function of autophagy in neurodegenerative diseases

Y Kiriyama, H Nochi - International journal of molecular sciences, 2015 - mdpi.com
… with neurodegeneration in adulthood. In this review, we focus on the recent findings …
the autophagic process and the involvement of autophagy in neurodegenerative diseases. …

Targeting autophagy in neurodegenerative diseases

RL Vidal, S Matus, L Bargsted, C Hetz - Trends in pharmacological …, 2014 - cell.com
… Figure 1Autophagy impairment in neurodegenerative diseases. Possible defects that could
alter the regulation and induction of macroautophagy in various neurodegenerative disorders…

Autophagy in neurodegenerative disease: friend, foe or turncoat?

RA Nixon - Trends in neurosciences, 2006 - cell.com
… the nervous system is so vulnerable to diseases that impair lysosomal system function, and
… to neurodegenerative disease have functions in the endocytic and autophagic pathways [ …

Neuronal autophagy and neurodegenerative diseases

JH Son, JH Shim, KH Kim, JY Ha, JY Han - Experimental & molecular …, 2012 - nature.com
Disease causing proteins affecting various types of autophagy in common neurodegenerative
diseases. Familial forms of the common neurodegenerative diseases, such as AD, PD, HD …