[HTML][HTML] Neurodevelopmental LincRNA microsyteny conservation and mammalian brain size evolution
E Lewitus, WB Huttner - PloS one, 2015 - journals.plos.org
E Lewitus, WB Huttner
PloS one, 2015•journals.plos.orgThe mammalian neocortex has undergone repeated selection for increases and decreases
in size and complexity, often over relatively short evolutionary time. But because probing
developmental mechanisms across many species is experimentally unfeasible, it is
unknown whether convergent morphologies in distantly related species are regulated by
conserved developmental programs. In this work, we have taken advantage of the
abundance of available mammalian genomes to find evidence of selection on genomic …
in size and complexity, often over relatively short evolutionary time. But because probing
developmental mechanisms across many species is experimentally unfeasible, it is
unknown whether convergent morphologies in distantly related species are regulated by
conserved developmental programs. In this work, we have taken advantage of the
abundance of available mammalian genomes to find evidence of selection on genomic …
The mammalian neocortex has undergone repeated selection for increases and decreases in size and complexity, often over relatively short evolutionary time. But because probing developmental mechanisms across many species is experimentally unfeasible, it is unknown whether convergent morphologies in distantly related species are regulated by conserved developmental programs. In this work, we have taken advantage of the abundance of available mammalian genomes to find evidence of selection on genomic regions putatively regulating neurogenesis in large- versus small-brained species. Using published fetal human RNA-seq data, we show that the gene-neighborhood (i.e., microsynteny) of long intergenic non-coding RNAs (lincRNAs) implicated in cortical development is differentially conserved in large-brained species, lending support to the hypothesis that lincRNAs regulating neurogenesis are selectively lost in small-brained species. We provide evidence that this is not a phenomenon attributable to lincRNA expressed in all tissue types and is therefore likely to represent an adaptive function in the evolution of neurogenesis. A strong correlation between transcription factor-adjacency and lincRNA sequence conservation reinforces this conclusion.
![](/scholar/images/qa_favicons/plos.org.png)