Addiction is a worldwide public health problem and this article reviews scientific advances in
identifying the role of neuroinflammation in the genesis, maintenance, and treatment of
substance use disorders. With an emphasis on neuroimaging techniques, this review
examines human studies of addiction using positron emission tomography to identify
binding of translocator protein (TSPO), which is upregulated in reactive glial cells and
activated microglia during pathological states. High TSPO levels have been shown in …