Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
W Qin, T Yang, L Ho, Z Zhao, J Wang, L Chen… - Journal of Biological …, 2006 - ASBMB
Nicotinamide adenine dinucleotide (NAD)+-dependent sirtuins have been identified to be
key regulators in the lifespan extending effects of calorie restriction (CR) in a number of
species. In this study we report for the first time that promotion of the NAD+-dependent
sirtuin, SIRT1-mediated deacetylase activity, may be a mechanism by which CR influences
Alzheimer disease (AD)-type amyloid neuropathology. Most importantly, we report that the
predicted attenuation ofβ-amyloid content in the brain during CR can be reproduced in …
key regulators in the lifespan extending effects of calorie restriction (CR) in a number of
species. In this study we report for the first time that promotion of the NAD+-dependent
sirtuin, SIRT1-mediated deacetylase activity, may be a mechanism by which CR influences
Alzheimer disease (AD)-type amyloid neuropathology. Most importantly, we report that the
predicted attenuation ofβ-amyloid content in the brain during CR can be reproduced in …