Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia
MA van der Kooij, F Groenendaal, A Kavelaars… - Brain research …, 2008 - Elsevier
Besides its established function in erythropoiesis, erythropoietin (EPO) is currently also
appreciated for its neuroprotective effects. The detrimental sequelae of prolonged cerebral
hypoxia and ischemia have been shown to attenuate by EPO treatment. After binding to the
EPO receptor, EPO is capable of initiating a cascade of events which–via different pathways–
may lead to neuroprotection. The circumstances that determine which specific signalling
route (s) are activated by EPO are largely unknown. We aim to provide the reader with a …
appreciated for its neuroprotective effects. The detrimental sequelae of prolonged cerebral
hypoxia and ischemia have been shown to attenuate by EPO treatment. After binding to the
EPO receptor, EPO is capable of initiating a cascade of events which–via different pathways–
may lead to neuroprotection. The circumstances that determine which specific signalling
route (s) are activated by EPO are largely unknown. We aim to provide the reader with a …
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