Neurotrophins: roles in neuronal development and function
EJ Huang, LF Reichardt - Annual review of neuroscience, 2001 - annualreviews.org
▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of
receptor tyrosine kinases and p75NTR, a member of the TNF receptor superfamily. Through
these, neurotrophins activate many signaling pathways, including those mediated by ras
and members of the cdc-42/ras/rho G protein families, and the MAP kinase, PI-3 kinase, and
Jun kinase cascades. During development, limiting amounts of neurotrophins function as …
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of
receptor tyrosine kinases and p75NTR, a member of the TNF receptor superfamily. Through
these, neurotrophins activate many signaling pathways, including those mediated by ras
and members of the cdc-42/ras/rho G protein families, and the MAP kinase, PI-3 kinase, and
Jun kinase cascades. During development, limiting amounts of neurotrophins function as …
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